Released on a WHIM.
نویسنده
چکیده
studies with CLL and MCL have provided support for this explanation (Buchner et al11; M. F. M. de Rooij, J. J. Buggy, and M.S., manuscript in preparation). In this perspective, it is tempting to speculate that combining these agents with anti-CD47 may turn out to be a highly efficacious treatment for NHL patients: once the malignant B cells have been forced out of their protective growthand survival-supporting microenvironment into the circulation, they are more accessible and vulnerable for the action of anti-CD47, preventing their dissemination and priming the fully exposed malignant B cells for being attacked and eaten by the macrophages. This would make a promising rational combination therapy for complete eradication of lymphoma, spread or not! Conflict-of-interest disclosure: The author declares no competing financial interests. ■
منابع مشابه
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عنوان ژورنال:
- Blood
دوره 118 18 شماره
صفحات -
تاریخ انتشار 2011